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De Mey JC. De Baerdemaeker L. De Laat M. Rolly G., The onset of neuromuscular block at the masseter muscle as a predictor of optimal intubating conditions with rocuronium. European Journal of Anaesthesiology. 16(6):387-9, 1999.
Although after an intubating dose of rocuronium satisfactory intubating conditions are achieved before the onset time at the adductor pollicis, the authors examined the possibility that measurement of the relaxation of the masseter muscle is a more appropriate guide when determining the intubating time. Simultaneous accelerometry with a 0.1-Hz single twitch stimulation of the chin and thumb was performed in 20 patients after 0.6 mg/kg rocuronium. The authors observed a significantly more brief mean lag time and onset time at the masseter muscle (22.5 and 61 vs. 32.5 and 160 s). The corresponding mean relaxation at the onset time was also significantly more pronounced at the masseter muscle (99.6 vs. 97.6%). A mean onset time at the masseter muscle of 61 seconds as produced by rocuronium corresponds clinically with excellent or good intubating conditions. From these results, the authors suggest that measurement of the onset time of muscle relaxation at the masseter muscle appears to be a better predictor of good intubating conditions than measurements made using the adductor pollicis muscle after administration of rocuronium.
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